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Metalloenzymes

Natural product nitrosation

Nature Chemical Biology volume 6, pages 636–637 (2010)Cite this article

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Many natural products are decorated with oxygenated nitrogens, but enzymes capable of forming a stable nitroso species have been elusive. A new study reports the identification of a copper-containing C-nitrososynthase that tightly controls the oxidation state of an aromatic amine to yield the natural product 4-hydroxy-3-nitrosobenzamide.

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Figure 1: N-oxygenation strategies in natural product biosynthesis.

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Authors and Affiliations

  1. Roland D. Kersten is at the Departments of Pharmacology, Chemistry and Biochemistry and the Center for Marine Biotechnology and Biomedicine of the Scripps Institution of Oceanography, University of California, San Diego, USA.,

    Roland D Kersten

  2. Pieter C. Dorrestein is at the Departments of Pharmacology, Chemistry and Biochemistry, the Center for Marine Biotechnology and Biomedicine of the Scripps Institution of Oceanography, and the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, USA.,

    Pieter C Dorrestein

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  1. Roland D Kersten
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  2. Pieter C Dorrestein
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Correspondence to Pieter C Dorrestein.

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The authors declare no competing financial interests.

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Kersten, R., Dorrestein, P. Natural product nitrosation. Nat Chem Biol 6, 636–637 (2010). https://doi.org/10.1038/nchembio.425

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