Through simultaneous binding to more than one site in a single protein, multivalent small molecules can achieve huge increases in potency. This 'avidity effect' has been demonstrated in BET bromodomain-containing proteins with bivalent probes that represent some of the most potent BET inhibitors to date.
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Owen, D. Doubling down on BET inhibition. Nat Chem Biol 12, 991–992 (2016). https://doi.org/10.1038/nchembio.2242
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DOI: https://doi.org/10.1038/nchembio.2242
