The essential metabolic cofactor coenzyme A was believed to be produced by biosynthesis from pantothenate in all eukaryotic cells. Rescue experiments in systems depleted of CoA have shown that a phosphorylated CoA biosynthetic intermediate can pass through eukaryotic membranes to serve as an alternative source.
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de Villiers, M., Strauss, E. Jump-starting CoA biosynthesis. Nat Chem Biol 11, 757–758 (2015). https://doi.org/10.1038/nchembio.1912
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DOI: https://doi.org/10.1038/nchembio.1912