Biological sulfonate incorporation is mediated by 3′-phosphoadenosine-5′-phosphosulfate–dependent sulfotransferases and, to a lesser extent, arylsulfate sulfotransferases. An unusual two-enzyme strategy for sulfonate mobilization involving both types of sulfotransferases has been revealed during antibiotic biosynthesis, which uses a new polyketide as the sulfonate shuttle.
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References
Armstrong, J.I. & Bertozzi, C.R. Curr. Opin. Drug Disc. 3, 502–515 (2000).
Malojcić, G. & Glockshuber, R. Antioxid. Redox Signal. 13, 1247–1259 (2010).
Tang, X. et al. Nat. Chem. Biol. 9, 10.1038/nchembio.1310 (4 Aug 2013).
Kalan, L., Perry, J., Koteva, K., Thaker, M. & Wright, G. J. Bacteriol. 195, 167–171 (2013).
Mougous, J.D., Green, R.E., Williams, S.J., Brenner, S.E. & Bertozzi, C.R. Chem. Biol. 9, 767–776 (2002).
McCarthy, J.G. et al. ACS Chem. Biol. 7, 1994–2003 (2012).
Kobashi, K., Fukaya, Y., Kim, D.-H., Akao, T. & Takebe, S. Arch. Biochem. Biophys. 245, 537–539 (1986).
Malojcić, G. et al. Proc. Natl. Acad. Sci. USA 105, 19217–19222 (2008).
Funabashi, M. et al. ChemBioChem 11, 184–190 (2009).
Kaysser, L. et al. J. Biol. Chem. 285, 12684–12694 (2010).
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Van Lanen, S. A sulfonate relay revealed. Nat Chem Biol 9, 602–603 (2013). https://doi.org/10.1038/nchembio.1319
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DOI: https://doi.org/10.1038/nchembio.1319
