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Immunology

Cytosolic DNA sensing unraveled

Nature Chemical Biology volume 9, pages 533–534 (2013)Cite this article

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A Corrigendum to this article was published on 18 October 2013

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DNA in the cytosol activates immune responses by binding sensors such as cGAMP synthase (cGAS). A set of studies reveal the structural mechanism of DNA sensing and show that cGAS produces a cyclic 2′-5′-linked dinucleotide, a new cellular second messenger.

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Figure 1: Model for 2′3′-cGAMP production by cGAS.

Change history

  • 25 September 2013

    In the version of this article initially published, the sentence "Three papers now report that cGAS produces a new type of second messenger molecule1,4,5" did not also attribute the finding to reference 6. The error has been corrected in the HTML and PDF versions of the article.

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  1. Daniel Panne is in the European Molecular Biology Laboratory Grenoble, Grenoble, France.,

    Daniel Panne

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  1. Daniel Panne
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Correspondence to Daniel Panne.

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Panne, D. Cytosolic DNA sensing unraveled. Nat Chem Biol 9, 533–534 (2013). https://doi.org/10.1038/nchembio.1318

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