Overcoming drug resistance requires drug–protein interactions that persist in spite of mutations, but such interactions are difficult to characterize. Two-dimensional infrared spectroscopy can reveal the dynamics of how key molecular groups interact, allowing new insights into how some drugs overcome resistance.
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Cheatum, C. Mechanisms of potency. Nature Chem 5, 152–153 (2013). https://doi.org/10.1038/nchem.1586
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DOI: https://doi.org/10.1038/nchem.1586
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