Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Supramolecular chemistry

A hydrophobic haven for base pairs

Hydrogen-bonded dimers of one and two base-pair nucleotides can be stabilized inside the hydrophobic pocket provided by self-assembled molecular cages. The results could bring DNA-based computing a step closer to reality.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Mono- and dinucleotide base pairs in water can be stabilized by encapsulation in self-assembled molecular cages.

References

  1. Sawada, T. et al. Nature Chem. 1, 53–56 10.1038/nchem.100 (2009).

    Article  CAS  Google Scholar 

  2. Fujita, M. et al. Acc. Chem. Res. 38, 371–380 (2005).

    Article  Google Scholar 

  3. Yoshizawa, M. et al. J. Am. Chem. Soc. 122, 6311–6312 (2000).

    Article  CAS  Google Scholar 

  4. Nakabayashi, K. et al. J. Am. Chem. Soc. 126, 16694–16695 (2004).

    Article  CAS  Google Scholar 

  5. Yoshizawa, M. et al. Science 312, 251–254 (2006).

    Article  CAS  Google Scholar 

  6. Ono, K. et al. Angew. Chem. Int. Ed. 46, 1803–1806 (2007).

    Article  CAS  Google Scholar 

  7. Yoshizawa, M. et al. J. Am. Chem. Soc. 127, 13456–13457 (2005).

    Article  CAS  Google Scholar 

  8. Thuong, T. N. & Hélène, C. Angew. Chem. Int. Ed. Engl. 32, 666–690 (1993).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Thomas, J. A hydrophobic haven for base pairs. Nature Chem 1, 25–26 (2009). https://doi.org/10.1038/nchem.135

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchem.135

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing