Tumours are highly complex and contain multiple cell types. Cancer-associated fibroblasts are now shown to have a critical role in directly leading cancer cell invasion. This intercellular interaction relies on a mechanically active cadherin-based junction, and CAF-led invasion is demonstrated to require E-cadherin in the cancer cell.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Determinants of renal cell carcinoma invasion and metastatic competence
Nature Communications Open Access 04 October 2021
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hu, M. et al. Cancer Cell 13, 394–406 (2008).
Gaggioli, C. et al. Nat. Cell Biol. 9, 1392–1400 (2007).
De Wever, O. et al. FASEB J. 18, 1016–1018 (2004).
Calvo, F. et al. Nat. Cell Biol. 15, 637–646 (2013).
Labernadie, A. et al. Nat. Cell Biol. 19, 224–237 (2017).
Foty, R. A. & Steinberg, M. S. Dev. Biol. 278, 255–263 (2005).
Lecuit, T. & Yap, A. S. Nat. Cell Biol. 17, 533–539 (2015).
Egeblad, M., Nakasone, E. S. & Werb, Z. Dev. Cell 18, 884–901 (2010).
Shamir, E. R. & Ewald, A. J. Nat. Rev. Mol. Cell Biol. 15, 647–664 (2014).
Weber, G. F., Bjerke, M. A. & DeSimone, D. W. Dev. Cell 22, 104–115 (2012).
Derksen, P. W. B. et al. Dis. Model. Mech. 4, 347–358 (2011).
Berx, G. & van Roy, F. Cold Spring Harb. Perspect. Biol. 1, a003129 (2009).
Rodriguez, F. J., Lewis-Tuffin, L. J. & Anastasiadis, P. Z. Biochim. Biophys. Acta 1826, 23–31 (2012).
Wang, H. et al. Cancer Cell 27, 193–210 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Ewald, A. Pulling cells out of tumours. Nat Cell Biol 19, 147–149 (2017). https://doi.org/10.1038/ncb3484
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb3484
This article is cited by
-
Determinants of renal cell carcinoma invasion and metastatic competence
Nature Communications (2021)
-
Cell motility in cancer invasion and metastasis: insights from simple model organisms
Nature Reviews Cancer (2018)