Tumours reprogram their metabolism to maximize macromolecule biosynthesis for growth. However, which of the common tumour-associated metabolic activities are critical for proliferation remains unclear. Glutamate-derived glutamine is now shown to satisfy the glutamine needs of glioblastoma, indicating that glutamine anaplerosis is dispensable for growth.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Crosstalk between autophagy and metabolic regulation of cancer stem cells
Molecular Cancer Open Access 06 February 2020
-
Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors
Cell Death & Disease Open Access 27 February 2018
-
Glutaminase 2 expression is associated with regional heterogeneity of 5-aminolevulinic acid fluorescence in glioblastoma
Scientific Reports Open Access 22 September 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1038%2Fncb3278/MediaObjects/41556_2015_Article_BFncb3278_Fig1_HTML.jpg)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1038%2Fncb3278/MediaObjects/41556_2015_Article_BFncb3278_Fig2_HTML.jpg)
References
Ye, J. et al. EMBO J. 29, 2082–2096 (2010).
Mashimo, T. et al. Cell 159, 1603–1614 (2014).
Wise, D. R. et al. Proc. Natl Acad. Sci. USA 105, 18782–18787 (2008).
Cheng, T. et al. Proc. Natl Acad. Sci. USA 108, 8674–8679 (2011).
Wang, J. B. et al. Cancer Cell 18, 207–219 (2010).
Tardito, S. et al. Nat. Cell Biol. 17, 1556–1568 (2015).
Kung, H. N., Marks, J. R. & Chi, J. T. PLoS Genet. 7, e1002229 (2011).
Carey, B. W., Finley, L. W., Cross, J. R., Allis, C. D. & Thompson, C. B. Nature 518, 413–416 (2015).
Gamberino, W. C., Berkich, D. A., Lynch, C. J., Xu, B. & LaNoue, K. F. J. Neurochem. 69, 2312–2325 (1997).
Zhang, J. et al. Mol. Cell 56, 205–218 (2014).
Gross, M. I. et al. Mol. Cancer Ther. 13, 890–901 (2014).
Cardaci, S. et al. Nat Cell Biol. 17, 1317–1326 (2015).
Birsoy, K. et al. Cell 162, 540–551 (2015).
Sullivan, L. B. et al. Cell 162, 552–563 (2015).
Ben-Sahra, I., Howell, J. J., Asara, J. M. & Manning, B. D. Science 339, 1323–1328 (2013).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Krall, A., Christofk, H. Rethinking glutamine addiction. Nat Cell Biol 17, 1515–1517 (2015). https://doi.org/10.1038/ncb3278
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb3278
This article is cited by
-
Crosstalk between autophagy and metabolic regulation of cancer stem cells
Molecular Cancer (2020)
-
Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors
Cell Death & Disease (2018)
-
Cancer heterogeneity is not compatible with one unique cancer cell metabolic map
Oncogene (2017)
-
The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
Scientific Reports (2017)
-
Glutaminase 2 expression is associated with regional heterogeneity of 5-aminolevulinic acid fluorescence in glioblastoma
Scientific Reports (2017)