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A mammalian pexophagy target

Nature Cell Biology volume 17, pages 1371–1373 (2015)Cite this article

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Protein ubiquitylation in mammals is known to trigger selective autophagy of peroxisomes through a process termed pexophagy. The physiological peroxisomal target for pexophagy-related ubiquitylation has been controversial, but two studies have now identified the protein PEX5 as the real candidate.

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Figure 1: Protein modifications on H. sapiens PEX5L (long isoform) that regulate pexophagy.
Figure 2: Signalling of pexophagy by ROS, hypoxia and inhibition of PEX5 export from peroxisomes.

References

  1. Shaid, S., Brandts, C. H., Serve, H. & Dikic, I. Cell Death Diff. 20, 21–30 (2013).

    Article  CAS  Google Scholar 

  2. Liu, X., Ma, C. & Subramani, S. Curr. Opin. Cell Biol. 24, 484–489 (2012).

    Article  CAS  Google Scholar 

  3. Okumoto, K., Noda, H. & Fujiki, Y. J. Biol. Chem. 289, 14089–14108 (2014).

    Article  CAS  Google Scholar 

  4. Kim, P. K., Hailey, D. W., Mullen, R. T. & Lippincott-Schwartz, J. Proc. Natl Acad. Sci. USA 105, 20567–20574 (2008).

    Article  CAS  Google Scholar 

  5. Yamashita, S., Abe, K., Tatemichi, Y. & Fujiki, Y. Autophagy 10, 1549–1564 (2014).

    Article  CAS  Google Scholar 

  6. Zhang, J. et al. Nat. Cell Biol. 17, 1259–1269 (2015).

    Article  CAS  Google Scholar 

  7. Nordgren, M. et al. Autophagy 11, 1326–1340 (2015).

    Article  CAS  Google Scholar 

  8. Braverman, N., Dodt, G., Gould, S. J. & Valle, D. Hum. Mol. Genet. 7, 1195–1205 (1998).

    Article  CAS  Google Scholar 

  9. Deosaran, E. et al. J. Cell Sci. 126, 939–952 (2013).

    Article  CAS  Google Scholar 

  10. Alexander, A., Kim, J. & Walker, C. L. Autophagy 6, 672–673 (2010).

    Article  Google Scholar 

  11. Apanasets, O. et al. Traffic 15, 94–103 (2014).

    Article  CAS  Google Scholar 

  12. Grou, C. P. et al. Cell. Mol. Life Sci. 66, 254–262 (2009).

    Article  CAS  Google Scholar 

  13. Ma, C., Hagstrom, D., Polley, S. G. & Subramani, S. J. Biol. Chem. 288, 27220–27231 (2013).

    Article  CAS  Google Scholar 

  14. Walter, K. M. et al. Cell Metab. 20, 882–897 (2014).

    Article  CAS  Google Scholar 

  15. Vara, D. & Pula, G. Curr. Mol. Med. 14, 1103–1125 (2014).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

S.S. is supported by NIH grant DK41737.

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  1. Division of Biological Sciences, Suresh Subramani is in the Section of Molecular Biology, University California, San Diego, California 92093-0322, USA,

    Suresh Subramani

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  1. Suresh Subramani
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Correspondence to Suresh Subramani.

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Subramani, S. A mammalian pexophagy target. Nat Cell Biol 17, 1371–1373 (2015). https://doi.org/10.1038/ncb3253

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