Autophagy is an intracellular degradation system that is mediated by orchestrated functions of membranes and proteins. A genetic screen in Caenorhabditis elegans revealed that O-linked N-acetylglucosamine modification of the SNARE protein SNAP-29 negatively regulates SNARE-dependent fusion between autophagosomes and lysosomes. This regulatory mechanism is conserved in mammals.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Zinc oxide nanoparticles harness autophagy to induce cell death in lung epithelial cells
Cell Death & Disease Open Access 27 July 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Guo, B. et al. Nat. Cell Biol. 16, 1215–1226 (2014).
Tsukada, M. & Ohsumi, Y. FEBS Lett. 333, 169–174 (1993).
Nakatogawa, H., Suzuki, K., Kamada, Y. & Ohsumi, Y. Nat. Rev. Mol. Cell Biol. 10, 458–467 (2009).
Mizushima, N., Yoshimori, T. & Ohsumi, Y. Annu. Rev. Cell Dev. Biol. 27, 107–132 (2011).
Mizushima, N. & Komatsu, M. Cell 147, 728–741 (2011).
Choi, A. M., Ryter, S. W. & Levine, B. N. Engl. J. Med. 368, 651–662 (2013).
Tian, Y. et al. Cell 141, 1042–1055 (2010).
Zhang, Y. et al. Cell 136, 308–321 (2009).
Bond, M. R. & Hanover, J. A. Annu. Rev. Nutr. 33, 205–229 (2013).
Slawson, C., Copeland, R. J. & Hart, G. W. Trends Biochem. Sci. 35, 547–555 (2010).
Marsh, S. A., Powell, P. C., Dell'italia, L. J. & Chatham, J. C. Life Sci. 92, 648–656 (2013).
Wang, P. et al. Proc. Natl Acad. Sci. USA 109, 17669–17674 (2012).
Kumar, A. et al. J. Biol. Chem. 289, 13543–13553 (2014).
Itakura, E., Kishi-Itakura, C. & Mizushima, N. Cell 151, 1256–1269 (2012).
Takáts, S. et al. J. Cell Biol. 201, 531–539 (2013).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Mizushima, N. Sugar modification inhibits autophagosome–lysosome fusion. Nat Cell Biol 16, 1132–1133 (2014). https://doi.org/10.1038/ncb3078
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb3078
This article is cited by
-
Zinc oxide nanoparticles harness autophagy to induce cell death in lung epithelial cells
Cell Death & Disease (2017)
-
The Nobel Prize: an appetizer before the feast
Science Bulletin (2016)