Collective cell migration is characterized by the maintenance of intercellular contacts during cell movement. The maintenance of N-cadherin-based junctions during collective migration is now shown to be facilitated by their treadmilling from the cell front to the rear, followed by N-cadherin endocytosis and recycling to the leading edge.
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E.H. and D.P. contributed equally to this work.
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Hirata, E., Park, D. & Sahai, E. Retrograde flow of cadherins in collective cell migration. Nat Cell Biol 16, 621–623 (2014). https://doi.org/10.1038/ncb2995
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DOI: https://doi.org/10.1038/ncb2995
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