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Signal integration by GSK3 kinases in the root

Signal integration is central to the regulation of patterning during plant development. During lateral root initiation, a signalling pathway controlled by the phloem-secreted TDIF peptide is found to activate the auxin signalling pathway independently of auxin, through phosphorylation of ARF transcription factors by GSK3 (Shaggy-like) kinases.

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Figure 1: The GSK3 kinase BIN2 as a central signalling hub during plant morphogenesis.

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Correspondence to Teva Vernoux.

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Galvan-Ampudia, C., Vernoux, T. Signal integration by GSK3 kinases in the root. Nat Cell Biol 16, 21–23 (2014). https://doi.org/10.1038/ncb2898

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