Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Anthrax receptors position the spindle

Spindle orientation plays a pivotal role in tissue morphogenesis. An asymmetric anthrax receptor cap is revealed to promote activation of a formin to orient the spindle along the planar cell polarity (PCP) axis in zebrafish dorsal epiblast cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Polarity at different scales.
Figure 2: Possible mechanisms for spindle orientation and centring.

References

  1. Morin, X. & Bellaiche, Y. Dev. Cell 21, 102–119 (2011).

    Article  CAS  Google Scholar 

  2. Minc, N. & Piel, M. Trends Cell Biol. 22, 193–200 (2012).

    Article  Google Scholar 

  3. Gong, Y., Mo, C. & Fraser, S. E. Nature 430, 689–693 (2004).

    Article  CAS  Google Scholar 

  4. Segalen, M. et al. Dev. Cell 19, 740–752 (2010).

    Article  CAS  Google Scholar 

  5. Gibson, W. T. et al. Cell 144, 427–438 (2011).

    Article  CAS  Google Scholar 

  6. Minc, N., Burgess, D. & Chang, F. Cell 144, 414–426 (2011).

    Article  CAS  Google Scholar 

  7. Castanon, I. et al. Nat. Cell Biol. 15, 28–39 (2013).

    Article  CAS  Google Scholar 

  8. Siller, K. H. & Doe, C. Q. Nat. Cell Biol. 11, 365–374 (2009).

    Article  CAS  Google Scholar 

  9. Fink, J. et al. Nat. Cell Biol. 13, 771–778 (2011).

    Article  CAS  Google Scholar 

  10. Mayer, M. et al. Nature 467, 617–621 (2010).

    Article  CAS  Google Scholar 

  11. Lee, L. et al. J. Cell Biol. 144, 947–961 (1999).

    Article  CAS  Google Scholar 

  12. Dumont, J. et al. Dev. Biol. 301, 254–265 (2007).

    Article  CAS  Google Scholar 

  13. Kiyomitsu, T. & Cheeseman, I. M. Nat. Cell Biol. 14, 311–317 (2012).

    Article  CAS  Google Scholar 

  14. Kimura, K. & Kimura, A. Proc. Natl Acad. Sci. USA 108, 137–142 (2011).

    Article  CAS  Google Scholar 

  15. Dogterom, M. & Yurke, B. Science 278, 856–860 (1997).

    Article  CAS  Google Scholar 

  16. Pecreaux, J. et al. Curr. Biol. 16, 2111–2122 (2006)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Nicolas Minc or Matthieu Piel.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Minc, N., Piel, M. Anthrax receptors position the spindle. Nat Cell Biol 15, 11–13 (2013). https://doi.org/10.1038/ncb2664

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb2664

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing