It is well documented that polyploid cells exist in mammalian tissues such as the placenta and liver, but their function and the mechanisms for their formation have remained elusive. Two studies now identify a role for atypical E2F transcription factors in promoting polyploidy in mammals and challenge present theories about the function of polyploidy.
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References
Lee, H. O., Davidson, J. M. & Duronio, R. J. Genes Dev. 23, 2461–2477 (2009).
De Veylder, L., Larkin, J. C. & Schnittger, A. Trends Plant Sci. 16, 624–634 (2011).
Chen, H. Z. et al. Nat. Cell Biol. 14, 1192–1202 (2012).
Pandit, S. K. et al. Nat. Cell Biol. 14, 1181–1191 (2012).
Ullah, Z. et al. Genes Dev. 22, 3024–3036 (2008).
Ouseph, M. M. et al. Dev. Cell 22, 849–862 (2012).
Li, J. et al. Dev. Cell 14, 62–75 (2008).
Celton-Morizur, S., Merlen, G., Couton, D. & Desdouets, C. Cell Cycle 9, 460–466 (2010).
Gentric, G., Celton-Morizur, S. & Desdouets, C. Clin. Res. Hepatol. Gastroenterol. 36, 29–34 (2012).
Celton-Morizur, S. & Desdouets, C. Adv. Exp. Med. Biol. 676, 123–135 (2010).
Zielke, N. et al. Nature 480, 123–127 (2011).
Bramsiepe, J. et al. PLoS Genet. 6, e1000996 (2010).
Mehrotra, S. et al. Genes Dev. 22, 3158–3171 (2008).
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Meserve, J., Duronio, R. Atypical E2Fs drive atypical cell cycles. Nat Cell Biol 14, 1124–1125 (2012). https://doi.org/10.1038/ncb2609
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DOI: https://doi.org/10.1038/ncb2609