After food consumption, insulin-secreting pancreatic β-cells detect increased glucose and incretin hormones, and respond by releasing insulin. Wolfram syndrome 1, a protein that mitigates endoplasmic reticulum (ER) stress, is now shown to regulate insulin synthesis and release — revealing a molecular point of convergence between the ER stress and insulin release pathways.
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Lemaire, K., Schuit, F. Integrating insulin secretion and ER stress in pancreatic β-cells. Nat Cell Biol 14, 979–981 (2012). https://doi.org/10.1038/ncb2594
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DOI: https://doi.org/10.1038/ncb2594
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