A precise role for the canonical Wnt pathway in maintaining pluripotency in mouse embryonic stem cells (mESCs) has been debated. Four recent reports add pieces to the puzzle and together these results may help establish a robust model.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Noise-processing by signaling networks
Scientific Reports Open Access 03 April 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Sato, N., Meijer, L., Skaltsounis, L., Greengard, P. & Brivanlou, A. H. Nat. Med. 10, 55–63 (2004).
Lyashenko, N. et al. Nat. Cell Biol. 13, 753–761 (2011).
Yi, F. et al. Nat. Cell Biol. 13, 762–770 (2011).
Wray, J. et al. Nat. Cell Biol. 13, 838–845 (2011).
ten Berge, D. et al. Nat. Cell Biol. 13, 1070–1075 (2011).
Ying, Q. L. et al. Nature 453, 519–523 (2008).
Cole, M. F., Johnstone, S. E., Newman, J. J., Kagey, M. H. & Young, R. Genes Dev. 22, 746–755 (2008).
Marson, A. et al. Cell 134, 521–533 (2008).
Tam, W. L. et al. Stem Cells 26, 2019–2031 (2008).
Yi, F., Pereira, L. & Merrill, B. J. Stem Cells 26, 1951–1960 (2008).
Nichols, J. & Smith, A. Cell Stem Cell 4, 487–492 (2009).
Doble, B. W., Patel, S., Wood, G. A., Kockeritz, L. K. & Woodgett, J. R. Dev. Cell 12, 957–971 (2007).
Ogawa, K., Nishinakamura, R., Iwamatsu, Y., Shimosato, D. & Niwa, H. Biochem. Biophys. Res. Commun. 343, 159–166 (2006).
Anton, R., Kestler, H. A. & Kuhl, M. FEBS Lett. 581, 5247–5254 (2007).
Soncin, F. et al. Stem Cells 27, 2069–2080 (2009).
Hanna, J. et al. Cell Stem Cell 4, 513–524 (2009).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Niwa, H. Wnt: What's Needed To maintain pluripotency?. Nat Cell Biol 13, 1024–1026 (2011). https://doi.org/10.1038/ncb2333
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb2333
This article is cited by
-
Prognostic implication of SOX2 expression in small intestinal adenocarcinoma
Virchows Archiv (2021)
-
Noise-processing by signaling networks
Scientific Reports (2017)
-
Mitotic and mitogenic Wnt signalling
The EMBO Journal (2012)