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Migration without a clutch

During cell migration, actin retrograde flow is counteracted by integrin-mediated adhesion to the underlying matrix, providing traction for forward movement. But in the absence of this 'clutch' mechanism, some types of cells adapt their actin polymerization to maintain similar migration speeds.

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Figure 1: Dendritic cells can switch between integrin-dependent and -independent modes of migration.

References

  1. Mitchison, T. J. & Cramer, L. P. Cell 84, 371–379 (1996).

    Article  CAS  Google Scholar 

  2. Mitchison, T. & Kirschner, M. Neuron 1, 761–772 (1988).

    Article  CAS  Google Scholar 

  3. Lin, C.-H. & Forscher, P. Neuron 14, 763–771 (1995).

    Article  CAS  Google Scholar 

  4. Medeiros, N. A., Burnette, D. T. & Forscher, P. Nature Cell Biol. 8, 216–226 (2006).

    Article  Google Scholar 

  5. Jurado, C., Haserick, J. R. & Lee, J. Mol. Biol. Cell 16, 507–518 (2005).

    Article  CAS  Google Scholar 

  6. Shimada, T. et al. J. Cell Biol. 181, 817–829 (2008).

    Article  CAS  Google Scholar 

  7. Bard, L. et al. J. Neurosci. 28, 5879–5890 (2008).

    Article  CAS  Google Scholar 

  8. Rankawitz . et al. Nature Cell Biol. 11, 1438–1443 (2009).

    Article  Google Scholar 

  9. Friedl. P et al. Eur. J. Immunol. 28, 2331–2343 (1998).

    Article  CAS  Google Scholar 

  10. Malawista, S. E. & de Boisflefleury Chevance, A. Proc. Natl Acad. Sci. USA 94, 11577–11582 (1997).

    Article  CAS  Google Scholar 

  11. Lämmermann, T. et al. Nature 453, 51–55 (2008).

    Article  Google Scholar 

  12. Miyoshi, T. et al. J. Cell Biol. 175, 947–955 (2006).

    Article  CAS  Google Scholar 

  13. Mogilner, A. Cur. Opin. Cell Biol. 18, 32–39 (2006).

    Article  CAS  Google Scholar 

  14. Hu, K. et al. Science 315, 111–115 (2007).

    Article  CAS  Google Scholar 

  15. Iwadate, Y. & Yumura, S. J. Cell Sci. 121, 1314–1324 (2008).

    Article  CAS  Google Scholar 

  16. Munevar, S., Wang, Y. L. & Dembo, M. Mol. Biol. Cell 12, 3947–3954 (2001).

    Article  CAS  Google Scholar 

  17. Charras, G. & Pauluch, E. Nature Rev. Mol. Cell Biol. 9, 730–736 (2008).

    Article  CAS  Google Scholar 

Download references

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Narumiya, S., Watanabe, N. Migration without a clutch. Nat Cell Biol 11, 1394–1396 (2009). https://doi.org/10.1038/ncb1209-1394

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