The tumour suppressor p53 triggers either cell-cycle arrest or apoptosis. Now, arginine methylation joins a panoply of other post-translational modifications that regulate p53. PRMT5 mediates p53 methylation, which disposes the cell to arrest rather than death.
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Berger, S. Out of the jaws of death: PRMT5 steers p53. Nat Cell Biol 10, 1389–1390 (2008). https://doi.org/10.1038/ncb1208-1389
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DOI: https://doi.org/10.1038/ncb1208-1389
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