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Polycystins: inhibiting the inhibitors

Nature Cell Biology volume 7, pages 1164–1165 (2005)Cite this article

Polycystin-1 and -2 — two integral membrane proteins that are mutated in polycystic kidney disease — regulate the cell cycle by preventing nuclear localization of the pro-proliferative helix-loop-helix (HLH) protein Id2. This novel mechanism for restraining Id proteins has important implications for our understanding of the nature of polycystic kidney disease and perhaps other proliferative disorders.

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Figure 1: PC2 sequesters Id2 in the cytoplasm.

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  1. Memorial Sloan-Kettering Cancer Center, Box 241, 1275 York Avenue, New York City, 10021, NY, USA

    Robert Benezra

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  1. Robert Benezra
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Benezra, R. Polycystins: inhibiting the inhibitors. Nat Cell Biol 7, 1164–1165 (2005). https://doi.org/10.1038/ncb1205-1164

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