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Receptor regulation: β-arrestin moves up a notch

Nature Cell Biology volume 7, pages 1159–1161 (2005)Cite this article

β-arrestin, a protein known to regulate the signalling, trafficking and degradation of mammalian seven-transmembrane-spanning receptors, has now been identified as a regulator of ubiquitination and degradation of the Notch receptor in Drosophila melanogaster.

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Figure 1: Notch signalling and degradation (a) Extracellular domains of the Notch receptor and its ligand, Delta, interact and lead to Notch activation, as well as proteolytic cleavage of Notch at the cell membrane.

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Authors and Affiliations

  1. Department of Medicine, Duke University Medical Center, Durham, 27710, North Carolina, USA

    Sudha K. Shenoy

  2. Department of Medicine and Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Durham, 27710, North Carolina, USA

    Robert J. Lefkowitz

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  1. Sudha K. Shenoy
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  2. Robert J. Lefkowitz
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Shenoy, S., Lefkowitz, R. Receptor regulation: β-arrestin moves up a notch. Nat Cell Biol 7, 1159–1161 (2005). https://doi.org/10.1038/ncb1205-1159

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