Loss of tissue organization, including disruption of epithelial polarity, is a feature of many carcinomas. Activation of the oncogenic receptor tyrosine kinase, ErbB2, induces alterations in epithelial architecture, but the mechanisms underlying this effect are poorly understood. New data suggests that the polarity proteins, Par6 and atypical PKC, may affect epithelial polarity and cell survival through interactions with an ErbB2 receptor complex.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1038%2Fncb1106-1220/MediaObjects/41556_2006_Article_BFncb11061220_Fig1_HTML.jpg)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1038%2Fncb1106-1220/MediaObjects/41556_2006_Article_BFncb11061220_Fig2_HTML.jpg)
References
Aranda, V. et al. Nature Cell Biol. 8, 1235–1245 (2006).
Gibson, M.C. & Perrimon, N. Curr. Opin. Cell Biol. 15, 747–752 (2003).
Bilder, D., Li, M. & Perrimon, N. Science 289, 113–116 (2000).
Kiyono, T. et al. Proc. Natl Acad. Sci. USA 94, 11612–11616 (1997).
Lee, S.S., Weiss, R.S. & Javier, R.T. Proc. Natl Acad. Sci. USA 94, 6670–6675 (1997).
Nakagawa, S. & Huibregtse, J.M. Mol. Cell Biol. 20, 8244–8253 (2000).
Debnath, J. & Brugge, J.S. Nature Rev. Cancer 5, 675–688 (2005).
Muthuswamy, S.K. et al. Nature Cell Biol. 3, 785–792 (2001).
Debnath, J. et al. Cell 111, 29–40 (2002).
Guo, W. et al. Cell 126, 489–502 (2006).
Muller, W.J. et al. Cell 54, 105–115 (1988).
Ozdamar, B. et al. Science 307, 1603–1609 (2005).
Liu, H., Radisky, D.C., Wang, F. & Bissell, M.J. J. Cell Biol. 164, 603–612 (2004).
Muthuswamy, S.K. Cell 126, 443–445 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Walker, S., Brugge, J. SePARating polarity and proliferation in ErbB2 oncogenesis. Nat Cell Biol 8, 1220–1222 (2006). https://doi.org/10.1038/ncb1106-1220
Issue Date:
DOI: https://doi.org/10.1038/ncb1106-1220