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A-kinase anchoring proteins: different partners, different dance

Nature Cell Biology volume 7, pages 1050–1051 (2005)Cite this article

How do cells achieve specific and efficient control over a wide spectrum of activities in the context of a limited protein repertoire? A possible answer comes from the recent demonstration that utilization of distinct enzymes by the same A-kinase anchoring protein (AKAP) depends on the AKAP-bound substrate, thus vastly increasing the diversity of AKAP-mediated protein regulation.

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Figure 1: The same AKAP mediates regulation of two distinct types of ion channel using different enzymes

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  1. Department of Pharmacology, Columbia University Medical Center, 630 W. 168th St., New York, 10032, NY, USA

    Lei Chen & Robert S. Kass

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  1. Lei Chen
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  2. Robert S. Kass
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Chen, L., Kass, R. A-kinase anchoring proteins: different partners, different dance. Nat Cell Biol 7, 1050–1051 (2005). https://doi.org/10.1038/ncb1105-1050

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