The transcription factor Hand1 is required for cell-fate determination during placental development. Recent work shows that release of Hand1 from the nucleolus controls differentiation of trophoblast stem cells into trophoblast giant cells, and this switch is controlled by the antagonistic activities of HICp40 and Polo-like kinase-4 (Plk4).
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Tanenbaum, M., Medemao, R. Cell fate in the Hand of Plk4. Nat Cell Biol 9, 1127–1129 (2007). https://doi.org/10.1038/ncb1007-1127
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DOI: https://doi.org/10.1038/ncb1007-1127
