Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

PARtners for endocytosis

The evolutionarily conserved PAR3–PAR6–aPKC–Cdc42 complex has a well-established role in cell polarity. The exact job of PAR proteins in polarity is not known, but the finding that they affect endocytosis casts new light on their function.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Role of anterior PAR proteins in endocytosis.
Figure 2: A model for the role of anterior PARs in polarity establishment.

References

  1. Kemphues, K. J., Priess, J. R., Morton, D. G. & Cheng, N. S. Cell 52, 311–320 (1988).

    Article  CAS  Google Scholar 

  2. Balklava, Z., Pant, S., Fares, H. & Grant, B. D. Nature Cell Biol. 9, 1066–1073 (2007).

    Article  CAS  Google Scholar 

  3. Kaksonen, M., Toret, C. P. & Drubin, D. G. Nature Rev. Mol. Cell Biol. 7, 404–414 (2006).

    Article  CAS  Google Scholar 

  4. Motegi, F. & Sugimoto, A. Nature Cell Biol. 8, 978–985 (2006).

    Article  CAS  Google Scholar 

  5. Munro, E., Nance, J. & Priess, J. R. Dev. Cell 7, 413–424 (2004).

    Article  CAS  Google Scholar 

  6. Schonegg, S. & Hyman, A. A. Development 133, 3507–3516 (2006).

    Article  CAS  Google Scholar 

  7. Nishimura, T. & Kaibuchi, K. Dev. Cell 13, 15–28 (2007).

    Article  CAS  Google Scholar 

  8. Suzuki, A. & Ohno, S. J. Cell Sci. 119, 979–987 (2006).

    Article  CAS  Google Scholar 

  9. Andrews, R. & Ahringer, J. PLoS ONE 2, e493 (2007).

    Article  Google Scholar 

  10. Macara, I. G. & Spang, A. Cell 125, 419–421 (2006).

    Article  CAS  Google Scholar 

  11. Kroschewski, R., Hall, A. & Mellman, I. Nature Cell Biol. 1, 8–13 (1999).

    Article  CAS  Google Scholar 

  12. Lu, H. & Bilder, D. Nature Cell Biol. 7, 1232–1239 (2005).

    Article  Google Scholar 

  13. Pelissier, A., Chauvin, J. P. & Lecuit, T. Curr. Biol. 13, 1848–1857 (2003).

    Article  CAS  Google Scholar 

  14. Marco, E., Wedlich-Soldner, R., Li, R., Altschuler, S. J. & Wu, L. F. Cell 129, 411 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wissler, F., Labouesse, M. PARtners for endocytosis. Nat Cell Biol 9, 1027–1029 (2007). https://doi.org/10.1038/ncb0907-1027

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0907-1027

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing