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Skipping into the E2F1-destruction pathway

Nature Cell Biology volume 1, pages E5–E7 (1999)Cite this article

Abstract

F-box proteins act as specificity factors for the ubiquitination, and thus degradation, of target proteins. New results point to the importance of F-box proteins in controlling the transcriptional programs that regulate development and the cell cycle.

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Figure 1: F-box proteins are interchangeable adaptors that link a core ubiquitin ligase (SKP1–CDC53/CUL-1) with a wide array of substrates.
Figure 2: The amounts and activity of E2F-1 are controlled in a cell-cycle-dependent way.

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Authors and Affiliations

  1. Verna and Marrs McLean Department of Biochemistry,

    J. Wade Harper & Stephen J. Elledge

  2. Howard Hughes Medical Institute and Department of Biochemistry, Baylor College of Medicine, Houston, 77030, Texas, USA

    J. Wade Harper & Stephen J. Elledge

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  1. J. Wade Harper
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  2. Stephen J. Elledge
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Correspondence to J. Wade Harper.

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Harper, J., Elledge, S. Skipping into the E2F1-destruction pathway. Nat Cell Biol 1, E5–E7 (1999). https://doi.org/10.1038/8952

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