Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Filling the GAP for dynamin

Endocytosis in eukaryotic cells involves numerous specialized protein complexes and lipid domains. One particularly intriguing protein is dynamin, a large GTPase that is very different from other GTPases. Now, phospholipase D has been identified as surprising regulator of dynamin's GTPase activity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A schematic representation of a model for the function of phospholipase D in endocytosis.

References

  1. Danino, D., Moon, K. H. & Hinshaw, J. E. J. Struct. Biol. 147, 259–267 (2004).

    Article  CAS  Google Scholar 

  2. Sever, S., Muhlberg, A. B. & Schmid, S. L. Nature. 398, 481–486 (1999).

    Article  CAS  Google Scholar 

  3. Lee, C. S. et al. Nature Cell Biol. 8, 477–484 (2006).

    Article  CAS  Google Scholar 

  4. Warnock, D. E., Terlecky, L. J. & Schmid, S. L. EMBO J. 14, 1322–1328 (1995).

    Article  CAS  Google Scholar 

  5. Shen, Y., Xu, L. & Foster, D. A. Mol. Cell Biol. 21, 595–602 (2001).

    Article  CAS  Google Scholar 

  6. Jenkins, G. M. & Frohman, M. A. Cell Mol. Life Sci. 62, 2305–2316 (2005).

    Article  CAS  Google Scholar 

  7. Chen, Y. J., Zhang, P., Egelman, E. H. & Hinshaw, J. E. Nature Struct. Mol. Biol. 11, 574–575 (2004).

    Article  CAS  Google Scholar 

  8. Merrifield, C. J, Feldman, M. E., Wan, L. & Almers, W. Nature Cell Biol. 4, 691–698 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hinshaw, J. Filling the GAP for dynamin. Nat Cell Biol 8, 432–433 (2006). https://doi.org/10.1038/ncb0506-432

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0506-432

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing