Staphylococcal α-hemolysin proteins form membrane pores that can be engineered to detect the concentration and identity of analytes, even at the single-molecule level. Bayley and colleagues now describe a method to use engineered α-hemolysin with ion-binding sites built into its barrel for simultaneously sensing the concentrations of two or more divalent metal ions in solution. (See p. 1005).
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DeWitt, N. Technical Reports. Nat Biotechnol 18, 915 (2000). https://doi.org/10.1038/79369
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DOI: https://doi.org/10.1038/79369