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Cell Culture and Animal Models of Viral Hepatitis. Part I: Hepatitis B

Abstract

Despite the existence of a preventative vaccine, HBV represents a substantial threat to public health, suggesting the need for research to develop new treatments to combat the disease. The authors review the available in vitro and in vivo models, including recently developed transgenic and chimeric mouse models.

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Acknowledgements

This work was supported in part by a grant from the American Cancer Society: RPG-00-066-01-CCE (to C.G.) and the following grants from NIH: RO1-DK 46057 (to J.R.C.), RO1-DK 39137 (to N.R.C.), and the Liver Research Core Center grant DK-P30-41296.

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Guha, C., Mohan, S., Roy-Chowdhury, N. et al. Cell Culture and Animal Models of Viral Hepatitis. Part I: Hepatitis B. Lab Anim 33, 37–46 (2004). https://doi.org/10.1038/laban0704-37

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