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Toxicology and pathology considerations for the design of juvenile animal studies

Lab Animal volume 37, pages 206–209 (2008)Cite this article

Abstract

Although exposure to drugs or toxicants can affect children and adults very differently, many compounds lack specific safety information for children. Studies in juvenile animals can help researchers assess pediatric patients' potential response to certain chemicals. Juvenile studies are highly sensitive to animal age, sex and species and must be planned with care to prevent misinterpretation of experimental data. The author reviews considerations for the design of these studies, focusing on toxicological and pathological aspects.

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Acknowledgements

I thank Kim Ehman of RTI International for her critical review of the manuscript and Ann Marie Hauck for preparation of the manuscript.

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  1. Experimental Pathology Laboratories, Inc., PO Box 12766, Research Triangle Park, 27709, NC

    John Curtis Seely

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  1. John Curtis Seely
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Correspondence to John Curtis Seely.

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Seely, J. Toxicology and pathology considerations for the design of juvenile animal studies. Lab Anim 37, 206–209 (2008). https://doi.org/10.1038/laban0508-206

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