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A retrospective review of postapproval monitoring at a large academic institution

Lab Animal volume 44, pages 395–401 (2015)Cite this article

Abstract

Institutional Animal Care and Use Committees (IACUCs) are federally mandated to ensure the welfare of animals used in research, testing and teaching. An IACUC must oversee institutional animal care and use programs and promote compliance with all regulations and policies. Postapproval monitoring (PAM) is one administrative tool that an IACUC can implement to help fulfill its federal and societal responsibility. Here, the authors describe the PAM program at a large academic institution, considering the program's accomplishments and how the program has changed since its inception. The authors also provide a retrospective analysis of compliance records during the first 10 y of the program, which demonstrate improved compliance following initiation of PAM.

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Figure 1
Figure 2: Annual compliance percentage during 2005–2014, including and excluding self-reported adverse events.
Figure 3: Odds of compliance during 2005–2014 as observed in PAM records or predicted using a logistic regression model.

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Acknowledgements

We thank the Statistical Consulting Center of the Duke University Department of Statistical Science, and particularly Dr. Edwin Iversen, for excellent guidance on statistical analysis of our data. We thank Mr. Michael Gentile and Drs. Laura Hale and Anna Hampton for assistance in editing the manuscript.

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Authors and Affiliations

  1. Office of Animal Welfare Assurance, Duke University Medical Center, Durham, NC

    Deborah A. Vanderford,  Sonia Doss &  Ron E. Banks

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  1. Deborah A. Vanderford
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  2. Sonia Doss
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  3. Ron E. Banks
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Correspondence to Deborah A. Vanderford.

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The authors declare no competing financial interests.

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Vanderford, D., Doss, S. & Banks, R. A retrospective review of postapproval monitoring at a large academic institution. Lab Anim 44, 395–401 (2015). https://doi.org/10.1038/laban.856

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