Abstract
Evaluation of multiple major operative procedures can be a daunting task for IACUCs. Committee members need to know what a major operative procedure is, when multiple major operative procedures are permitted under the Animal Welfare Act, when permission from the Administrator of the US Department of Agriculture's Animal and Plant Health Inspection Service is required for multiple major operative procedures, and what information must be included when requesting such permission. The author discusses the intent and requirements for multiple major operative procedures under the Animal Welfare Act and describes best practices that IACUCs may use in evaluating multiple major operative procedures both within and across protocols.
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References
Code of Federal Regulations. Title 9, Ch. 1.
Animal and Plant Health Inspection Service. Final Rules: Animal Welfare; 9 CFR Parts 1 and 2. Federal Register 54, 36112–36163 (31 August 1989).
Public Health Service. Policy on Humane Care and Use of Laboratory Animals – Frequently Asked Questions. Animal Use and Management Question No. 13. (US Department of Health and Human Services, Washington, DC, 2006; revised 2013). http://grants.nih.gov/grants/olaw/faqs.htm#useandmgmt_13.
United States Department of Agriculture. Policy #14: Major Survival Surgery Dealers Selling Surgically-Altered Animals to Research. in Animal Care Policy Manual (USDA, Beltsville, MD, 2011). http://www.aphis.usda.gov/animal_welfare/policy.php?policy=14.
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Petervary, N. Best practices for IACUCs in the evaluation of multiple major operative procedures. Lab Anim 42, 330–333 (2013). https://doi.org/10.1038/laban.175
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DOI: https://doi.org/10.1038/laban.175