Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Performance of blood pressure to height ratio as a screening tool for elevated blood pressure in rural children: Ellisras Longitudinal Study

Abstract

There are complications in diagnosing hypertension in children and adolescents due to variation of blood pressure (BP) values to age, gender and height. This study was aimed at assessing whether the performance of BP-to-height ratio (BPHR) can be an effective tool for screening prehypertension and hypertension in Ellisras Longitudinal Study (ELS) children aged between 6 and 17 years. A number of the 9002 children aged 6–17 years who were part of the ELS underwent height and BP measurements using standard procedures. Receiver-operating characteristic curve was used to assess the accuracy of BPHR to screen children with prehypertension and hypertension. The optimal systolic BPHR (SBPHR) and diastolic BPHR (DBPHR) cut-off points for hypertension were determined. Sensitivity/specificity, positive predictive values and negative predictive values were calculated. The optimal thresholds for defining prehypertension was 0.77 in children aged 6–10 years and 0.73 in adolescents aged between 11 and 17 years for systolic BPHR and 0.55 in children and 0.53 in adolescents for diastolic BPHR, respectively. The corresponding values for hypertension stage 1 were 0.76 and 0.73 for SBPHR and 0.50 and 0.58 for DBPHR, respectively. BPHR can be used as an effective tool for screening both prehypertension and hypertension in ELS children aged 6–17 years.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Feber J, Ahmed M . Hypertension in children: new trends and challenges. Clin Sci 2010; 119: 151–161.

    Article  Google Scholar 

  2. Monyeki KD, Kemper HC . The risk factors for elevated blood pressure and how to address cardiovascular risk factors: a review in paediatric populations. J Hum Hypertens 2008; 22: 450–459.

    Article  Google Scholar 

  3. Kiessling SG, McClanahan KK, Omar HA . Obesity, hypertension, and mental health evaluation in adolescents: a comprehensive approach. Int J Adolesc Med Health 2008; 20: 5–16.

    Article  Google Scholar 

  4. Labadarios D, Steyn N, Maunder E, MacIntyre U, Swart R . The National Food Consumption Survey (NFCS)—children aged 1-9 years South Africa 1999. South Afr J Clin Nutr 2001; 14: 16.

    Google Scholar 

  5. Stergiou GS, Giovas PP, Kollias A, Rarra VC, Papagiannis J, Georgakopoulos D et al. Relationship of home blood pressure with target-organ damage in children and adolescents. Hypertens Res 2011; 34: 640–644.

    Article  Google Scholar 

  6. Hansen ML, Gunn PW, Kaelber DC . Underdiagnosis of hypertension in children and adolescents. JAMA 2007; 298: 874–879.

    Article  CAS  Google Scholar 

  7. Lu Q, Ma CM, Yin FZ, Liu BW, Lou DH, Liu XL . How to simplify the diagnostic criteria of hypertension in adolescents. J Hum Hypertens 2011; 25: 159–163.

    Article  CAS  Google Scholar 

  8. Xi B, Zhang M, Zhang T, Liang Y, Li S, Steffen LM . Hypertension screening using blood pressure to height ratio. Pediatrics 2014; 134: e106–e111.

    Article  Google Scholar 

  9. Kelishadi R, Bahreynian M, Heshmat R, Motlagh ME, Djalalinia S, Naji F et al. Accuracy of blood pressure-to-height ratio to define elevated blood pressure in children and adolescents: the CASPIAN-IV study. Pediatr Cardiol 2016; 37: 378–385.

    Article  Google Scholar 

  10. Sidiropoulos E, Jeffery A, Mackay S, Gallocher R, Forgey H, Chips C . South Africa Survey 1995/1996. South African Institute of Race and Relations: Johannesburg, South Africa, 1996, 234–360.

    Google Scholar 

  11. Statistics South Africa. Cause of Death in South Africa 1997-2001: Advance Release of Records of Death. Statistics South Africa: Pretoria, South Africa, 2002, 18–42.

  12. Monyeki KD, Van Lenthe FJ, Steyn NP . Obesity: does it occur in African children in a rural community in South Africa? Int J Epidemiol 1999; 28: 287–292.

    Article  CAS  Google Scholar 

  13. Monyeki KD, Cameron N, Getz B . Growth and nutritional status of rural South African children 3-10 years old: the Ellisras growth study. Am J Hum Biol 2000; 12: 42–49.

    Article  Google Scholar 

  14. Norton K, Olds T . Anthropometrica. University of New South Wales Press: Sydney, Australia, 1996.

    Google Scholar 

  15. National High Blood Pressure Education Program Working Group on High Blood Pressure in children and adolescents. The forth report on the diagnosis, evaluation and treatments of high blood pressure in children and adolescents. Pediatrics 2004; 114: 555–576.

    Article  Google Scholar 

  16. Mi J, Wang TY, Meng LH, Zhu GJ, Han SM, Zhong Y et al. Development of blood pressure reference standards for Chinese children and adolescents. Chin J Evidence Based Pediatr 2010; 5: 4–14.

    Google Scholar 

  17. Yan W, Liu F, Li X, Wu L, Zhang Y, Cheng Y et al. Blood pressure percentiles by age and height for non-overweight Chinese children and adolescents: analysis of the china health and nutrition surveys 1991–2009. BMC Pediatr 2013; 13: 1.

    Article  Google Scholar 

  18. Ejike CE . Blood pressure to height ratios as simple, sensitive and specific diagnostic tools for adolescent (pre) hypertension in Nigeria. Ital J Pediatr 2011; 37: 1.

    Article  Google Scholar 

  19. Rabbia F, Rabbone I, Totaro S, Testa E, Covella M, Berra E et al. Evaluation of blood pressure/height ratio as an index to simplify diagnostic criteria of hypertension in Caucasian adolescents. J Hum Hypertens 2011; 25: 623–624.

    Article  CAS  Google Scholar 

  20. Galescu O, George M, Basetty S, Predescu I, Mongia A, Ten S et al. Blood pressure over height ratios: simple and accurate method of detecting elevated blood pressure in children. Int J Pediatr 2012; 2012: 253497.

    Article  Google Scholar 

  21. Kelishadi R, Heshmat R, Ardalan G, Qorbani M, Taslimi M, Poursafa P et al. First report on simplified diagnostic criteria for pre-hypertension and hypertension in a national sample of adolescents from the Middle East and North Africa: the CASPIAN-III study. J Pediatr 2014; 90: 85–91.

    Article  Google Scholar 

  22. Kanchanaraksa S . Evaluation of Diagnostic and Screening Tests Validity and Reliability. John Hopkins University: Baltimore, MD, USA, 2008.

    Google Scholar 

Download references

Acknowledgements

The financial support received from Vrije University, Amsterdam, The Netherlands; University of Limpopo, South Africa; and the National Research Foundation (NRF) of South Africa for the Ellisras Longitudinal Study is also acknowledged with gratitude. Any opinions, findings and conclusions or recommendations expressed in this material are those of the authors and therefore the above-mentioned funding sources do not accept any liability in regard thereto. We are indebted to ELS administrators (Seleka PS, Makata TT, Makata W and Seleka S) for providing technical support in preparation of this manuscript. Malatji MJ and Monyeki MS (English educators of Makgoka high school) are thankfully acknowledged for editing the manuscript.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to K D Monyeki.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sekgala, M., Monyeki, K., Mogale, M. et al. Performance of blood pressure to height ratio as a screening tool for elevated blood pressure in rural children: Ellisras Longitudinal Study. J Hum Hypertens 31, 591–595 (2017). https://doi.org/10.1038/jhh.2017.25

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/jhh.2017.25

This article is cited by

Search

Quick links