Abstract
Triclosan (TCS) is a synthetic antibacterial chemical that is used in personal care products and is measurable in urine. Urinary TCS has been associated with allergy in children in Norway and the United States. A reasonable degree of temporal reliability of TCS urinary concentrations has been reported among US children as well as for Puerto Rican pregnant women. We examined the reliability of TCS measures in urine among Norwegian pregnant women. TCS was measured in spot urine samples collected in gestational weeks 17, 23, and 29 from 45 women in The Norwegian Mother and Child Cohort Study (MoBa) enrolled in 2007 and 2008. Spearman’s rank correlation coefficient (rs) and intraclass correlation coefficient (ICC) statistics were calculated. Fifty-six percent of the 45 women had a least one sample with a value above the method limit of detection (2.3 μg/l). The correlation coefficients were 0.61 for TCS concentrations at 17 and 23 weeks and 0.49 for concentrations at 17 and 29 weeks. For the three time points, the ICC was 0.49. The reliability of TCS concentrations in repeated urine samples from pregnant Norwegian women was reasonably good, suggesting a single urine sample can adequately represent TCS exposure during pregnancy.
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References
CDC. Fourth National Report on Human Exposure to Environmental Chemicals. Department of Health and Human Services. Centers for Disease Control and Prevention: Atlanta. 2009.
Sandborgh-Englund G, Adolfsson-Erici M, Odham G, Ekstrand J . Pharmacokinetics of triclosan following oral ingestion in humans. J Toxicol Environ Health A 2006; 69: 1861–1873.
Bertelsen RJ, Longnecker MP, Lovik M, Calafat AM, Carlsen KH, London SJ et al. Triclosan exposure and allergic sensitization in Norwegian children. Allergy 2013; 68: 84–91.
Savage JH, Matsui EC, Wood RA, Keet CA . Urinary levels of triclosan and parabens are associated with aeroallergen and food sensitization. J Allergy Clin Immunol 2012; 130: 453–460.
Teitelbaum SL, Britton JA, Calafat AM, Ye X, Silva MJ, Reidy JA et al. Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States. Env Res 2008; 106: 257–269.
Meeker JD, Cantonwine DE, Rivera-Gonzalez LO, Ferguson KK, Mukherjee B, Calafat AM et al. Distribution, variability, and predictors of urinary concentrations of phenols and parabens among pregnant women in Puerto Rico. Environ Sci Technol 2013; 47: 3439–3447.
Administration FUSFaD Triclosan: What Consumers Should Know 2012.
Eide AM . Analyse av triklosan i kosmetiske produkter. The Norwegian Food Control Authority: Oslo. 2003.
Scientific Committee on Consumer Safety. SCCS. Opinion on Triclosan Antimicrobial Resistance. The European Commission, 2010, Available from http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_023.pdf Accessed 18 November 2013.
Magnus P, Irgens LM, Haug K, Nystad W, Skjaerven R, Stoltenberg C . Cohort profile: the Norwegian Mother and Child Cohort Study (MoBa). Int J Epidemiol 2006; 35: 1146–1150.
Irgens LM . The Medical Birth Registry of Norway. Epidemiological research and surveillance throughout 30 years. Acta Obstet Gynecol Scand 2000; 79: 435–439.
Longnecker MP, Harbak K, Kissling GE, Hoppin JA, Eggesbo M, Jusko TA et al. The concentration of bisphenol A in urine is affected by specimen collection, a preservative, and handling. Env Res 2013; 126: 211–214.
Ye X, Kuklenyik Z, Needham LL, Calafat AM . Automated on-line column-switching HPLC-MS/MS method with peak focusing for the determination of nine environmental phenols in urine. Anal Chem 2005; 77: 5407–5413.
Ye X, Zhou X, Hennings R, Kramer J, Calafat AM . Potential external contamination with bisphenol A and other ubiquitous organic environmental chemicals during biomonitoring analysis: an elusive laboratory challenge. Environ Health Perspect 2013; 121: 283–286.
Barr DB, Wilder LC, Caudill SP, Gonzalez AJ, Needham LL, Pirkle JL . Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements. Environ Health Perspect 2005; 113: 192–200.
Committee AM. Measurement of near zero concentration: recording and reporting results that fall close to or below the detection limit. Analyst 2001; 126: 256–259.
Lassen TH, Frederiksen H, Jensen TK, Petersen JH, Main KM, Skakkebaek NE et al. Temporal variability in urinary excretion of bisphenol A and seven other phenols in spot, morning, and 24-h urine samples. Environ Res 2013; 126: 164–170.
CDC National Health and Nutrition Examination Survey 2007-2008 Data Documentation, Codebook, and Frequencies, Environmental Phenols (EPH_E) 2010.
Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL . Urinary concentrations of triclosan in the U.S. population: 2003-2004. Environ Health Perspect 2008; 116: 303–307.
CDC Laboratory Procedure Manual, 2011. Available from http://www.cdc.gov/nchs/data/nhanes/nhanes_09_10/EPH_F_met_phenols_parabens.pdf Accessed 18 November 2013.
Philippat C, Wolff MS, Calafat AM, Ye X, Bausell R, Meadows M et al. Prenatal exposure to environmental phenols: concentrations in amniotic fluid and variability in urinary concentrations during pregnancy. Environ Health Perspect 2013; 121: 1225–1231.
Nie L, Chu H, Liu C, Cole SR, Vexler A, Schisterman EF . Linear regression with an independent variable subject to a detection limit. Epidemiology 2010; 21 (Suppl 4): S17–S24.
Acknowledgements
The Norwegian Mother and Child Cohort Study is supported by the Norwegian Ministry of Health and the Ministry of Education and Research, NIH/NIEHS (contract no N01-ES-75558), NIH/NINDS (grant no. 1 UO1 NS 047537-01), and the Norwegian Research Council/FUGE (grant no. 151918/S10). This study was supported in part by the grants from the National Institute of Environmental Health Sciences (P30-ES010126, R01-ES021777, and K12-ES019852), the Intramural Research Program of the National Institute of Health (NIH), National Institute of Environmental Health Sciences (NIEHS). The involvement of the CDC was determined not to constitute engagement in human subject research. Human subjects committees at NIEHS and at the University of North Carolina also approved this study protocol. We acknowledge X. Ye, X. Zhou, J. Kramer, and T. Jia (CDC) for technical assistance in measuring TCS. We are grateful to all the participating families in Norway who take part in this ongoing cohort study. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the CDC.
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Bertelsen, R., Engel, S., Jusko, T. et al. Reliability of triclosan measures in repeated urine samples from Norwegian pregnant women. J Expo Sci Environ Epidemiol 24, 517–521 (2014). https://doi.org/10.1038/jes.2013.95
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DOI: https://doi.org/10.1038/jes.2013.95
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