Abstract
A novel versipelostatin (1) analogue, versipelostatin F (2) was isolated from Streptomyces versipellis 4083-SVS6. The structure of 2 was determined by the analyses of the spectroscopic data. Compound 2 inhibited the expression of GRP78 induced by 2-deoxyglucose with an IC50 value of 0.3 μM, which is 10-times more potent compared with that of 1.
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Ueda, Jy., Chijiwa, S., Takagi, M. et al. A Novel Versipelostatin Analogue, Versipelostatin F Isolated from Streptomyces versipellis 4083-SVS6. J Antibiot 61, 752–755 (2008). https://doi.org/10.1038/ja.2008.89
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DOI: https://doi.org/10.1038/ja.2008.89
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