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The NCATS Assay Guidance Manual programme: advancing the practice and rigour of preclinical translation
The Assay Guidance Manual programme, a translational science education and training initiative at the US National Center for Advancing Translational Sciences (NCATS), aims to help bridge the gap between research discoveries and the delivery of new therapies by creating and disseminating experimental protocols and standards for rigour in preclinical translational research.
National Center for Advancing Translational Sciences, Rockville, MD, USA. Present address: Molecular Pharmacology Laboratories, Applied and Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
National Center for Advancing Translational Sciences, Rockville, MD, USA. Present address: Novartis Institutes for Biomedical Research, Chemical Biology and Therapeutics, Cambridge, MA, USA.
Historically, drug discovery was performed virtually exclusively within pharmaceutical companies, which educated scientists recruited from academic training in both the general principles of the field and the particular practices of the company. The assay protocol manuals each company used for their internal research programmes were considered proprietary and not shared or published.
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Nature Reviews Drug Discovery21, 863-864 (2022)
doi: https://doi.org/10.1038/d41573-022-00170-7
Acknowledgements
The authors would like to thank all of the past and present AGM editorial board members for their tremendous help and support of the AGM programme. This work was supported by the Intramural Research Program of the NCATS, NIH.
References
Markossian, S. et al. (eds) Assay Guidance Manual (Eli Lilly & Company and the National Center for Advancing Translational Sciences, 2004).
Coussens, N. P. et al. Assay Guidance Manual: quantitative biology and pharmacology in preclinical drug discovery. Clin. Transl. Sci.11, 461–470 (2018).
