Both oncogenes and normal genes can mediate the development and progress of cancer. What used to separate their effects was cancer's dependence on, or 'addiction' to, oncogenes but not normal genes. Not any more.
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References
Felsher, D. W. & Bishop, J. M. Mol. Cell 4, 199–207 (1999).
Jain, M. et al. Science 297, 102–104 (2002).
Weinstein, I. B. Science 297, 63–64 (2002).
Shaffer, A. L. et al. Nature 454, 226–231 (2008).
Klein, U. et al. Nature Immunol. 7, 773–782 (2006).
Zhan, F. et al. Blood 108, 2020–2028 (2006).
Shaughnessy, J. D. Jr et al. Blood 109, 2276–2284 (2007).
Bergsagel, P. L. et al. Blood 106, 296–303 (2005).
Zhan, F. et al. Blood 99, 1745–1757 (2002).
Zhan, F. et al. Blood 101, 1128–1140 (2003).
Potter, M. Immunol. Rev. 194, 177–195 (2003).
Matsui, W. et al. Cancer Res. 68, 190–197 (2008).
Barlogie, B. et al. Blood 103, 20–32 (2004).
Hideshima, T., Mitsiades, C., Tonon, G., Richardson, P. G. & Anderson, K. C. Nature Rev. Cancer 7, 585–598 (2007).
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Shaughnessy, J. An unexpected addiction. Nature 454, 172–173 (2008). https://doi.org/10.1038/454172a
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DOI: https://doi.org/10.1038/454172a