Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Research Article
  • Published:

Lack of linkage between the corticotropin-releasing hormone (CRH) gene and bipolar affective disorder

Molecular Psychiatry volume 2, pages 483–485 (1997)Cite this article

Abstract

Corticotropin-releasing hormone (CRH) plays a key role in the regulation of the stress response. Abnormalities in CRH secretion have been documented in both the depression and manic phases of bipolar disorder (BPD). In the present study, we investigated genetic linkage between the CRH gene and BPD in 22 pedigrees. A highly informative, short tandem repeat (STR) polymorphism adjacent to the CRH gene on human chromosomal region 8q13 was used to examine linkage. Affected sibling pair (ASP) and the likelihood-based disequilibrium tests revealed nonsignificant values. We conclude that the CRH gene is not linked to BPD; if genes involved in the regulation of stress response are indeed linked to BPD, the search should be directed towards those that regulate CRH secretion or its effects on target tissues.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Developmental Endocrinology Branch (DEB), National Institute of Child Health and Human Development (NICHD), USA

    C A Stratakis & G P Chrousos

  2. Laboratory of Molecular and Cellular Biology (LMCB), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), USA

    N J Sarlis

  3. Clinical Neurogenetics Branch (CNB), National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, 20892, MD, USA

    J A Badner, E S Gershon & S D Detera-Wadleigh

  4. Department of Psychiatry and Human Behavior, Thomas Jefferson Medical College, Philadelphia, 19107, PA, USA

    W H Berrettini

  5. Genetics & Endocrinology, Georgetown University Children's Medical Center, DC 20007, Washington, USA

    C A Stratakis

Authors
  1. C A Stratakis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N J Sarlis
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W H Berrettini
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J A Badner
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G P Chrousos
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E S Gershon
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S D Detera-Wadleigh
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stratakis, C., Sarlis, N., Berrettini, W. et al. Lack of linkage between the corticotropin-releasing hormone (CRH) gene and bipolar affective disorder. Mol Psychiatry 2, 483–485 (1997). https://doi.org/10.1038/sj.mp.4000268

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.mp.4000268

Keywords

Search

Advanced search

Quick links