Abstract
It is unclear whether lower urinary tract symptoms (LUTS) cause erectile dysfunction (ED) independently or through common underlying pathophysiology and shared risk factors. The aim of this study was to investigate the effect of ED on the incidence of frequency and bother of LUTS. Target population consisted of men aged 50, 60 or 70 years residing in the study area in Finland in 1994. Questionnaires were mailed to 3143 men in 1994 and to 2837 of them 5 years later. The follow-up sample comprised 1683 men who responded to both baseline and follow-up surveys. ED was assessed by two questions on subject's ability to achieve or maintain an erection sufficient for intercourse and LUTS by the Danish Prostatic Symptom Score questionnaire. A dose–response relation was found between the severity of ED at baseline and the incidence of LUTS or bother during follow-up. After adjustment for the confounders, the incidence rate ratio (RR) of LUTS was higher in men with moderate (RR 1.5, 95% confidence interval (CI) 1.0–2.3) or severe ED (RR 2.3, 95% CI 1.4–3.8) than in those free of ED at entry. Compared with men free of ED at baseline, the RRs of urinary bother were 1.6 (95% CI 1.1–2.4), 1.9 (95% CI 1.1–3.2) and 2.2 (95% CI 1.1–4.3) for minimal, moderate or severe ED, respectively. In summary, ED is associated with an increased incidence of LUTS and bother. ED and LUTS may have a common underlying pathophysiology or shared risk factors.
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References
Li MK, Garcia LA, Rosen R . Lower urinary tract symptoms and male sexual dysfunction in Asia: a survey of ageing men from five Asian countries. BJU Int 2005; 96: 1339–1354.
Ponholzer A, Temml C, Obermayr R, Madersbacher S . Association between lower urinary tract symptoms and erectile dysfunction. Urology 2004; 64: 772–776.
Shiri R, Häkkinen J, Koskimäki J, Huhtala H, Auvinen A, Hakama M et al. Association between the bothersomeness of lower urinary tract symptoms and the prevalence of erectile dysfunction. J Sex Med 2005; 2: 438–444.
Rosen R, Altwein J, Boyle P, Kirby RS, Lukacs B, Meuleman E et al. Lower urinary tract symptoms and male sexual dysfunction: the multinational survey of the aging male (MSAM-7). Eur Urol 2003; 44: 637–649.
Braun M, Wassmer G, Klotz T, Reifenrath B, Mathers M, Engelmann U . Epidemiology of erectile dysfunction: results of the ‘Cologne Male Survey’. Int J Impot Res 2000; 12: 305–311.
Shiri R, Häkkinen JT, Hakama M, Huhtala H, Auvinen A, Tammela TL et al. Effect of lower urinary tract symptoms on the incidence of erectile dysfunction. J Urol 2005; 174: 205–209; discussion 209.
Moreira Jr ED, Lbo CF, Diament A, Nicolosi A, Glasser DB . Incidence of erectile dysfunction in men 40 to 69 years old: results from a population-based cohort study in Brazil. Urology 2003; 61: 431–436.
McVary KT . Erectile dysfunction and lower urinary tract symptoms secondary to BPH. Eur Urol 2005; 47: 838–845.
Rosen RC . Update on the relationship between sexual dysfunction and lower urinary tract symptoms/benign prostatic hyperplasia. Curr Opin Urol 2006; 16: 11–19.
Hansen BJ, Flyger H, Brasso K, Schou J, Nordling J, Thorup Andersen J et al. Validation of the self-administered Danish Prostatic Symptom Score (DAN-PSS-1) system for use in benign prostatic hyperplasia. Br J Urol 1995; 76: 451–458.
Davignon J, Ganz P . Role of endothelial dysfunction in atherosclerosis. Circulation 2004; 109 (Suppl 1): III27–III32.
Fleming I, Busse R . NO: the primary EDRF. J Mol Cell Cardiol 1999; 31: 5–14.
Gewaltig MT, Kojda G . Vasoprotection by nitric oxide: mechanisms and therapeutic potential. Cardiovasc Res 2002; 55: 250–260.
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Financial support for the study was provided by the Medical Research Fund of Tampere University Hospital.
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Shiri, R., Häkkinen, J., Koskimäki, J. et al. Erectile dysfunction influences the subsequent incidence of lower urinary tract symptoms and bother. Int J Impot Res 19, 317–320 (2007). https://doi.org/10.1038/sj.ijir.3901526
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DOI: https://doi.org/10.1038/sj.ijir.3901526
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