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Semiquantitative imaging measurement of baseline and vasomodulated normal prostatic blood flow using sildenafil

International Journal of Impotence Research volume 19, pages 110–113 (2007)Cite this article

Abstract

The physiologic variability of blood flow to the prostate has not been studied until this time. We report the vasoactive effects of sildenafil and phenylephrine on blood flow of the normal prostate. Sildenafil increases prostate blood flow by approximately 75% and phenylephrine reduces the flow incrementally. Administration of these drugs with dynamic contrast-enhanced magnetic resonance imaging may improve the diagnosis of cancerous tissue because according to the literature, tumor angiogenic vessels lack the vasoactive physiologic response of the normal tissue.

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Acknowledgements

We thank Jack Jesberger for reviewing the technical aspects of the MRI data.

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  1. Department of Radiology, University Hospitals of Cleveland, Cleveland, OH, USA

    J R Haaga, A Exner, B Fei & A Seftel

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  1. J R Haaga
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  2. A Exner
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  3. B Fei
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Correspondence to J R Haaga.

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Haaga, J., Exner, A., Fei, B. et al. Semiquantitative imaging measurement of baseline and vasomodulated normal prostatic blood flow using sildenafil. Int J Impot Res 19, 110–113 (2007). https://doi.org/10.1038/sj.ijir.3901486

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  • DOI: https://doi.org/10.1038/sj.ijir.3901486

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