Abstract
THE complex architecture of the limb cartilage pattern probably develops by the sequential segmentation and branching process of precartilaginous cell condensation under the control of positional signalling1,2 provided by the zone of polarizing activity (anteroposterior)3,4 and the apical ectodermal ridge (proximodistal)5. This signalling is monitored and interpreted in the mesenchymal cells and induces the position-specific response of subsets of genes. Homeobox genes may be responsible for the interpretation of signalling6–11. A correlation between limb pattern and expression domains of the homeobox genes in the upstream region of Hox/Chox-4 has been proposedia10–12. We have analysed the spatial expression pattern of the Chox-1 genes during development of chick limb buds. In contrast to genes in Hox/Chox-4 expressed coordinately along the anteroposterior axis10,11, homeobox genes in Chox-1 have unique and mutually exclusive expression domains along the proximodistal axis. We report here that the expression domains of the Chox-1 genes are closely related to the segmental structure of cartilage along the proximodistal axis, whereas the expression domains of the Chox-4 genes are related to the cartilage branching pattern.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Shubin, N. & Albrerch, P. Evol. Biol. 20, 319–387 (1986).
Oster, G. F., Shubin, N., Murray, J. D. & Albrech, P. Evolution 42, 862–884 (1988).
Saunders, J. W. J. J. exp. Zool. 108, 363–404 (1948).
Tickle, C., Summerbell, D. & Wolpert, L. Nature 254, 199–202 (1975).
Summerbell, D., Lewis, J. H. & Wolpert, L. Nature 244, 492–496 (1973).
Oliver, G. et al. Genes Dev. 3, 641–650 (1989).
Wilkinson, D. G., Bhatt, S., Cook, M., Boncinelli, E. & Krumlauf, R. Nature 341, 405–409 (1989).
Dollé, P., Izpisúa-Belmonte, J.-C., Falkenstein, H., Renucci, A. & Duboule, D. Nature 342, 767–772 (1989).
Simeone, A. et al. Nature 346, 763–766 (1990).
Nohno, T. et al. Cell 64, 1197–1205 (1991).
Izpisúa-Belmonte, J.-C., Tickle, C., Dollé, P., Wolpert, L. & Doboule, D. Nature 350, 585–589 (1991).
Dollé, P. & Duboule, D. EMBO J. 8, 1507–1515 (1989).
Hamburger, V. & Hamilton, H. L. J. Morph. 88, 49–92 (1951).
Oliver, G., DeRobertis, E. M., Wolpert, L. & Tickle, C. EMBO J. 9, 3093–3099 (1990).
Nardi, J. B. & Stocum, D. L. Differentiation 25, 27–31 (1983).
Crawford, K. & Stocum, D. L. Development 104, 703–712 (1988).
Aulthouse, A. L. & Solursh, M. Devl. Biol. 120, 377–384 (1987).
Yokouchi, Y., Ohsugi, K., Sasaki, H. & Kuroiwa, A. Development 113 (in the press).
Tautz, D. & Pfeiffle, C. Chromosoma 98, 81–85 (1989).
Acampora, D. et al. Nucleic Acids Res., 17, 10385–10402 (1989).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yokouchi, Y., Sasaki, H. & Kuroiwa, A. Homeobox gene expression correlated with the bifurcation process of limb cartilage development. Nature 353, 443–445 (1991). https://doi.org/10.1038/353443a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/353443a0
This article is cited by
-
Ectopic Fgf signaling induces the intercalary response in developing chicken limb buds
Zoological Letters (2018)
-
Anatomical integration of the sacral–hindlimb unit coordinated by GDF11 underlies variation in hindlimb positioning in tetrapods
Nature Ecology & Evolution (2017)
-
HoxA and HoxD expression in a variety of vertebrate body plan features reveals an ancient origin for the distal Hox program
EvoDevo (2014)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.