Nature, 404, 1018–1021 (2000).
In this Letter, we demonstrated active group II intron transposition to multiple ectopic sites and showed that movement to these new sites occurs via an RNA intermediate in a process termed retrotransposition. Of interest was whether retrotransposition occurs by reverse splicing of the intron RNA into RNA, single-stranded DNA and/or double-stranded DNA targets. Our results suggested that retrotransposition occurs predominantly by the intron reverse-splicing into an RNA target. However, subsequent experiments using a different intron donor have indicated that the selection method for retrotransposition events can strongly bias the interpretation of pathway (K. Ichiyanagi, A. Beauregard and M.B., unpublished results). The new data do not point to RNA-targeting as the principal means for intron retrotransposition, and DNA-based pathways must be considered as playing an important role.
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The online version of the original article can be found at 10.1038/35010029
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Cousineau, B., Lawrence, S., Smith, D. et al. Correction: Retrotransposition of a bacterial group II intron. Nature 414, 84 (2001). https://doi.org/10.1038/35102087
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DOI: https://doi.org/10.1038/35102087
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