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Stroboscopic NMR microscopy of the carotid artery

Nature volume 341, pages 321–323 (1989)Cite this article

Abstract

THE non-invasive measurement of vascular dynamics and elasticity is critical in understanding haemodynamic conditions of cardiovascular diseases such as hypertension and atherosclerosis1. Although there are numerous invasive and in vitro techniques2 for such measurements, until now non-invasive methods have been limited3. We have now obtained stroboscopic NMR images4,5 of the carotid arteries of 80-g rats. The change in the cross-sectional area of arteries of diameter ˜600–800 ptm was correlated with the change in absolute blood pressure. These are the first microimages6–9 of a dynamic system and enable the direct visualization of compliance, the non-invasive measurement of Young's modulus, the direct determination of the local effects of vasoconstrictors and vasodilators and the mapping of the entire cardiac cycle.

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Author notes

  1. Ronald W. Behling

    Present address: Squibb Institute for Medical Research, Princeton, New Jersey, NJ 08543, USA

  2. Helen K. Tubbs

    Present address: Cornell Medical School, New York, 10021, USA

  3. Lynn W. Jelinski: To whom correspondence should be addressed

Authors and Affiliations

  1. AT&T Bell Laboratories, Murray Hill, New Jersey, 07974, USA

    Ronald W. Behling, Helen K. Tubbs, Michael D. Cockman & Lynn W. Jelinski

Authors
  1. Ronald W. Behling
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  2. Helen K. Tubbs
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  3. Michael D. Cockman
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  4. Lynn W. Jelinski
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Behling, R., Tubbs, H., Cockman, M. et al. Stroboscopic NMR microscopy of the carotid artery. Nature 341, 321–323 (1989). https://doi.org/10.1038/341321a0

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