Abstract
The two strands of the DNA molecule are complementary but not identical. Hence, upon semiconservative replication, different parental DNA strands are segregated to daughter cells. A molecular analysis suggests that the process of fission yeast mating-type interconversion uses asymmetry of the DNA strands to generate a regular lineage of cellular differentiation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gurdon, J. B. J. Embryol. exp. Morph. 10, 622–640 (1962).
Holliday, R. & Pugh, J. E. Science 187, 226–232 (1975).
Gutz, H., Heslot, H., Leupoid, U. & Loprieno, N. in Handbook of Gentries (ed. King, R. C.) 395–446 (Plenum, New York, 1974).
Miyata, H. & Miyata, M. J. gen. appl. Microbiol. 27, 365–371 (1981).
Egel, R. & Gutz, H. Curr. Genet. 3, 5–12 (1981).
Beach, D. H. Nature 305, 682–687 (1983).
Beach, D. H. & Klar, A. J. S. EMBO J. 3, 603–610 (1984).
Egel, R. Curr. Genet. 8, 199–203 (1984).
Egel, R. Curr. Genet. 8, 205–210 (1984).
Crouse, H. V. Genetics 45, 1429–1434 (1960).
Watson, J. D. & Crick, F. Nature 171, 737–738 (1953).
Egel, R., Beach, D. H. & Klar, A. J. S. Proc. natn. Acad. Sci. U.S.A. 81, 3481–3485 (1984).
Klar, A. J. S. & Miglio, L. M. Cell 46, 725–731 (1986).
Piekarowica, A., Bickle, T. A., Shepherd, J. C. W. & Ineichen, K. J. molec. Biol. 146, 167–172 (1981).
Cairns, J. Nature 255, 197–200 (1975).
Beach, D. H. & Nurse, P. M. Nature 290, 140–142 (1981).
Orr-Weaver, T. L., Szostak, J. W. & Rothstein, R. J. Proc. natn. Acad. Sci. U.S.A. 78, 6254–6358 (1981).
Klar, A. J. S., Hicks, J. B. & Strathera, J. N. Cell 28, 551–561 (1982).
Rothstein, R. J. Meth. Enzym. 101, 202–211 (1983).
Iino, Y. & Yamamoto, M. Proc. natn. Acad. Sci. U.S.A. 82, 2447–2451 (1985).
Nurse, P. Molec. gen. Genet. 198, 497–502 (1985).
Haber, J. E. & Rogers, D. T. Nature 294, 768–770 (1982).
Southern, E. M. Molec. gen. Genet. 98, 503–517 (1985).
Modrich, P. & Roberts, R. J. Nucleases (eds Lin, S. M. & Roberts, R. J.) 109–154 (Cold Spring Harbor Laboratory, New York, 1982).
Brutlag, D., Schekman, R. & Kornberg, A. Proc. natn. Acad. Sci. U.S.A. 68, 2826–2830 (1971).
Brown, D. D. Cell 37, 359–365 (1984).
Sumper, M. in Pattern Formation (eds Malacinski, G. M. & Bryant, S. V.) 197–212 (Macmillan, New York, 1984).
Wilcox, M., Mitchison, G. J. & Smith, R. J. J. Cell Sci. 12, 707–711 (1973).
Nasmyth, K. Nature 302, 670–676 (1983).
Jensen, R. E. & Herskowitz, I. Cold Spring Harbor Symp. quant. Biol. 49, 97–104 (1984).
Sulston, J. E., Schierenberg, E., White, J. G. & Thomson, J. N. Devl Biol. 100, 64–119 (1983).
Sternberg, P. W. & Horvitz, H. R. A. Rev. Genet. 18, 489–524 (1984).
Maniatis, T., Fritsch, E. F. & Sambrook, J. Molecular Cloning: A Laboratory Manual. (Cold Spring Harbor, New York, 1982.)
Gutz, H. & Schmidt, H. Curr. Genet. 9, 325–331 (1985).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Klar, A. Differentiated parental DNA strands confer developmental asymmetry on daughter cells in fission yeast. Nature 326, 466–470 (1987). https://doi.org/10.1038/326466a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/326466a0
This article is cited by
-
RNA insertion in DNA as the imprint moiety: the fission yeast paradigm
Current Genetics (2019)
-
Amar Klar: A giant among scientists (1947–2017)
Journal of Biosciences (2017)
-
Vigor of survival determinism: subtle evolutionary gradualism interspersed with robust phylogenetic leaping
Theory in Biosciences (2017)
-
Sorting DNA with asymmetry: a new player in gene regulation?
Chromosome Research (2013)
-
Unbiased segregation of fission yeast chromosome 2 strands to daughter cells
Chromosome Research (2013)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.