Abstract
The introduction into lymphocytes of immunoglobulin-gene DNA that has been manipulated in vitro allows the production of novel antibodies. In this way, cell lines have been established that secrete hapten-specific antibodies in which the Fc portion has been replaced either with an active enzyme moiety or with polypeptide displaying c-myc antigenic determinants.
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Neuberger, M., Williams, G. & Fox, R. Recombinant antibodies possessing novel effector functions. Nature 312, 604–608 (1984). https://doi.org/10.1038/312604a0
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DOI: https://doi.org/10.1038/312604a0
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