Abstract
The autoimmune disease of the central nervous system (CNS), experimental allergic encephalomyelitis (EAE), is induced by challenge of genetically susceptible animals with spinal cord homogenates or myelin basic protein (MBP)1–4. Chronic and relapsing forms of the disease have some similarities to human demyelinating disorders, namely, multiple sclerosis3,5–7, and are of particular interest. EAE can be transferred passively with sensitized lymphoid cells into syngeneic animals8 but transferred EAE has been believed to have limited relevance to human disease because it is usually monophasic and manifested by minimal demyelination9. We report here that a single transfer of MBP-sensitized lymph node cells or T cells, in the absence of a peripheral antigen depot, leads to both acute EAE with significant primary demyelination, and chronic relapsing disease with lesions typical of demyelination over a long period. These findings have major implications for the immunological mechanisms involved in experimental and human demyelinating diseases.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Paterson, P. Y. & Day, E. D. Clin. Immun. Rev. 1, 581–697 (1982).
Stone, S. H. & Lerner, E. M. Ann. N.Y. Acad. Sci. 122, 227–241 (1965).
Wisniewski, H. M. & Keith, A. B. Ann. Neurol. 1, 144–148 (1977).
Brown, A. & McFarlin, D. A. Lab. Invest. 45, 278 (1981).
Raine, C. S., Snyder, D. H., Valsamis, M. P. & Stone, S. H. Lab. Invest. 31, 369–380 (1974).
Raine, C. S. in Multiple Sclerosis—Pathology, Diagnosis and Management (eds Hallpike, J., Adams, C. W. M. & Tourtellotte, W. W.) (Chapman & Hall, London, 1983).
Lassmann, H., Kitz, & Wisniewski, H. M. in Search for the Cause of Multiple Sclerosis and Other Chronic Diseases of the Central Nervous System (ed. Boese, A.) (Verlag Chemie, Weinhem, 1980).
Paterson, P. Y. J. exp. Med. 111, 119–136 (1960).
Stone, S. H., Snyder, S. H. & Raine, C. S. J. neurol. Sci. 60, 401–409 (1983).
Diebler, G. E., Martenson, R. E. & Kies, M. W. Prep. Biochem. 2, 139–165 (1972).
Pettinelli, C. B. & McFarlin, D. E. J. Immun. 127, 1420–1423 (1981).
Lewis, G. K. & Kamin, R. in Selected Methods in Cellular Immunology (eds Mishell, B. B. & Shugi, S. M.) (Freeman, California, 1980).
Stuart, A. E., Habeshaw, J. A. & Davidson, A. E. in Cellular Immunology (ed. Weir, D. M.) 1–6 (Blackwell, Oxford, 1978).
Raine, C. S., Barnett, L. B., Brown, A., Behar, T. & McFarlin, D. E. Lab. Invest. 43, 150–157 (1980).
McFarlin, D. E., Blank, S. E. & Kibler, R. F. J. Immun. 113, 712–715 (1974).
Panitch, H. & Ciccone, C. Ann. Neurol. 9, 433–438 (1981).
Fritz, R. B., Chou, C-H J. & McFarlin, D. E. J. Immun. 130, 1024–1026 (1983).
Raine, C. S., Traugott, U., Farooq, M., Bornstein, M. B. & Norton, W. T. Lab. Invest. 45, 174–182 (1981).
Lapin, E. P., Maker, H. S., Schipper, H. I., Weiss, C. & Lehrer, G. M. J. Neurochem. 26, 1289–1291 (1976).
Stone, S. H. Science 134, 619–620 (1961).
Panitch, H. S. & McFarlin, D. E. J. Immun. 119, 1134–1137 (1977).
Richert, J. R., Driscoll, B. F., Kies, M. W. & Alvord, E. C. Jr J. Immun. 122, 494–502 (1979).
Driscoll, B. F. & Kies, M. W. Science 203, 547–548 (1979).
Ben-Nun, A., Wekerle, H. S. & Cohen, I. R. Eur. J. Immun. 11, 195–199 (1981).
Omlin, F. X. et al. J. Cell Biol. 95, 242–248 (1982).
Traugott, E. L., Reinherz, C. S. & Raine, C. S. J. Neuroimmun. 4, 201–221 (1983).
Ting, J. P. Y., Shigekana, B. L., Linthicom, D. S., Weiner, L. P. & Frelinger, J. A. Proc. natn. Acad. Sci. U.S.A. 78, 3170–3174 (1981).
Day, E. D. Contemp. Topics molec. Immun. 8, 1–39 (1981).
Weigle, W. O. Adv. Immun. 30, 159–259 (1980).
Burger, D. R. & Vetto, R. M. Cell Immun. 70, 357–361 (1982).
Wisniewski, H. M. & Bloom, B. R. J. exp. Med. 141, 346–359 (1975).
Naparstek, Y. et al. Nature 300, 262–264 (1982).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mokhtarian, F., McFarlin, D. & Raine, C. Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice. Nature 309, 356–358 (1984). https://doi.org/10.1038/309356a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/309356a0
This article is cited by
-
An emerging potential of metabolomics in multiple sclerosis: a comprehensive overview
Cellular and Molecular Life Sciences (2021)
-
Field Synopsis and Re-analysis of Systematic Meta-analyses of Genetic Association Studies in Multiple Sclerosis: a Bayesian Approach
Molecular Neurobiology (2018)
-
NMR-Based Metabolomics Separates the Distinct Stages of Disease in a Chronic Relapsing Model of Multiple Sclerosis
Journal of Neuroimmune Pharmacology (2015)
-
IL-17 producing T cells in mouse models of multiple sclerosis and rheumatoid arthritis
Journal of Molecular Medicine (2012)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.