Abstract
Class II antigens of the major histocompatibility complex (MHC) consist of a family of closely related cell surface-expressed glycoproteins. These antigens, which are genetically polymorphic, control important aspects of the immune response1. At least three types of human class II antigens, namely, DR, DC and SB (refs 2–4), have been identified. All class II antigens are heterodimers composed of one α- and one β-chain. The genes for both types of subunits are encompassed within the MHC5,6. The general features of the DC and DR antigens have recently been elucidated7–15. Much less is known, however, about the SB molecules16. Here we describe the isolation of a cDNA clone as well as a genomic clone encoding a β-chain whose amino acid sequence is compatible with the partial amino-terminal sequence of SB β-chains16.
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References
Möller, E. Immun. Rev. 66, 5–187 (1982).
Tosi, R., Tanigaki, T., Centis, D., Ferrara, G. B. & Pressman, D. J. Expl Med. 148, 1592–1611 (1978).
Shaw, S., Kavathas, P., Pollack, M. S., Charmot, D. & Mawas, C. Nature 293, 745–749 (1981).
Terasaki, E. P. (ed.) Histocompatibility Testing 1980. (UCLA Tissue Typing Lab., Los Angeles, 1980).
Trowsdale, J. et al. Proc. natn. Acad. Sci. U.S.A. 80, 1972–1976 (1983).
Hood, L., Steinmetz, M. & Malissen, B. A. Rev. Immun. 1, 529–568 (1983).
Auffray, C. et al. Proc. natn. Acad. Sci. U.S.A. 79, 6337–6341 (1982).
Korman, A. J., Auffray, C., Schamboeck, A. & Strominger, J. L. Proc. natn. Acad. Sci. U.S.A. 79, 6013–6017 (1982).
Kratzin, H. et al. Hoppe Seyler's Z. physiol. Chem. 362, 1665–1669 (1981).
Schenning, L. et al. EMBO J. 3, 447–452 (1983).
Larhammar, D. et al. Cell 30, 153–161 (1982).
Larhammar, D. et al. Proc. natn. Acad. Sci. U.S.A. 79, 3687–3691 (1982).
Lee, J. S. et al. Nature 299, 750–752 (1982).
Long, E. O., Wake, C. T., Gorski, J. & Mach, B. EMBO J. 2, 389–394 (1983).
Yang, C.-Y. et al. Hoppe Seyler's Z. physiol. Chem. 363, 671–676 (1982).
Hurley, C. K., Shaw, S., Nadler, L., Schlossman, S. & Capra, J. D. J. exp. Med. 156, 1557–1562 (1982).
Long, E. O. et al. Proc. natn. Acad. Sci. U.S.A. 79, 7465–7469 (1982).
Wiman, K. et al. Proc. natn. Acad. Sci. U.S.A. 79, 1703–1707 (1982).
Gustafsson, K. et al. EMBO J. (submitted).
Larhammar, D. et al. Proc. natn. Acad. Sci. U.S.A. 80, 7313–7317 (1983).
Roux-Dosseto, M. et al. Proc. natn. Acad. Sci. U.S.A. 80, 6036–6040 (1983).
Maxam, A. M. & Gilbert, W. Meth. Enzym. 65, 499–560 (1980).
Grosveld, F. G. et al. Nucleic Acids Res. 10, 6715–6732 (1982).
Rigby, P. W. J., Dieckmann, M., Rhodes, C. & Berg, P. J. molec. Biol. 113, 237–251 (1977).
Böhme, J. et al. Nature 301, 82–84 (1983).
Southern, E. J. Molec. Biol. 98, 503–517 (1975).
Denhardt, D. T. Biochem. biophys. Res. Commun. 23, 641–646 (1966).
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Gustafsson, K., Emmoth, E., Widmark, E. et al. Isolation of a cDNA clone coding for an SB β-chain. Nature 309, 76–78 (1984). https://doi.org/10.1038/309076a0
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DOI: https://doi.org/10.1038/309076a0
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