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Evolution of the genes for the β subunits of human chorionic gonadotropin and luteinizing hormone

Nature volume 307, pages 37–40 (1984)Cite this article

Abstract

Nucleotide sequence comparisons of the single gene for the human luteinizing hormone gene β subunit with two of the seven genes for the human chorionic gonadotropin β subunit suggest that the β human chorionic gonadotropin genes have evolved from an ancestral β luteinizing hormone gene by a series of selected changes with very little neutral drift. Moreover, the 24 amino acid carboxy-terminal extension of the human chorionic gonadotropin β subunit appears to have arisen by a single base deletion that incorporated the 3′-untranslated region of the ancestral β luteinizing hormone gene into the coding region.

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Author notes

  1. Karen Talmadge & John C. Fiddes

    Present address: California Biotechnology Inc., 2450 Bayshore Frontage Road, Mountain View, 94043, California, USA

  2. Nikos C. Vamvakopoulos

    Present address: , 28 Kononos, Pagrati, Athens, Greece

Authors and Affiliations

  1. Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, New York, 11724, USA

    Karen Talmadge, Nikos C. Vamvakopoulos & John C. Fiddes

Authors
  1. Karen Talmadge
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  2. Nikos C. Vamvakopoulos
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  3. John C. Fiddes
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Talmadge, K., Vamvakopoulos, N. & Fiddes, J. Evolution of the genes for the β subunits of human chorionic gonadotropin and luteinizing hormone. Nature 307, 37–40 (1984). https://doi.org/10.1038/307037a0

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