Changes in geniculate cell size following brief monocular blockade of retinal activity in kittens

Abstract

When a kitten is subjected to monocular lid suture early in life, cells in laminae of the lateral geniculate nucleus (LGN) connected to the sutured eye grow less than normal and cells in those laminae connected to the non-sutured eye grow more than normal^1–5. These changes are seen primarily in the binocular segment of the LGN, which corresponds to the central visual field, and are due to competition either between intracortical afferents originating from the different LGN laminae, or directly among cells within the LGN^2,6. The afferent deprivation induced by lid suture, however, is not complete, as retinal ganglion cells fire tonically both in darkness and in light⁷. It is generally thought that this tonic retinal activity is necessary to maintain neuronal excitability at normal threshold in the central visual pathway^8–10. In the visual cortex of developing kittens, we previously showed a long-lasting change in ocular dominance of binocular cells by a brief blockade of retinal activity in one optic nerve¹¹. We report here that a complete blockade of retinal activity in one eye causes major changes in LGN cell size within 1 week. These changes occur throughout the LGN, including the monocular segment where binocular competition does not occur. The results indicate that tonic retinal activity may have an important role in the control of geniculate cell size.