Abstract
The HLA-D region of the human major histocompatibiiity complex (MHC) has been shown to be homologous to the murine I region in terms of both structure and function. Both regions encode class II MHC molecules which restrict T-lymphocyte interactions with antigen-presenting cells. We have recently described the MHC restriction and antigen specificities of human T-lymphocyte clones directed at strain A influenza virus1–3. The majority of T-lymphocyte clones recognized antigen in the context of cell surface interaction products encoded by HLA-D/DR genes. However, a few clones recognized antigen presented by cells histoincompatible for D/DR antigens. We report here that some of these clones recognize viral antigens in association with antigens encoded by genes identical with or closely linked to the recently described secondary B-cell (SB) locus of the MHC4,5. This is the first report that SB-restricted antigen recognition may form an integral part of normal, human immune responses.
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References
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Eckels, D., Lake, P., Lamb, J. et al. SB-restricted presentation of influenza and herpes simplex virus antigens to human T-Iymphocyte clones. Nature 301, 716–718 (1983). https://doi.org/10.1038/301716a0
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DOI: https://doi.org/10.1038/301716a0
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